Autism Research Database - Location Project Details | IACC

Project Element	Element Description
Project Title Project Title	Mechanisms of eIF4E-dependent Translational Control in Autism
Principal Investigator Principal Investigator	Sonenberg, Nahum
Description Description	Nahum Sonenberg, Ph.D., of McGill University, will explore the activity of a protein that helps regulate gene expression, and specifically the process by which proteins are generated, in many parts of the brain, with implications for treating autism spectrum disorder. The protein, called e-IF4E, has already been linked to autism-like deficits in animal models. Using human cells, Dr. Sonenberg's team will create different mutations affecting e-IF4E. They will then track which genes show altered expression as a result of the mutations. Since e-IF4E-controlled gene expression is already FDA-approved as a target for drug compounds, this work aims to bring researchers one step closer to exploiting e-IF4E to treat disorders on the autism spectrum.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	66667
Current Award Period Current Award Period	2016-2017
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	McGill University
Institute Location Institute Location	Canada
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Mechanisms of eIF4E-dependent Translational Control in Autism \| 33333 \| 2017 \|

Back to Top